Effect of Hypoxic Stress–Activated Polo-like Kinase 3 on Corneal Epithelial Wound Healing
Identifieur interne : 000568 ( Main/Exploration ); précédent : 000567; suivant : 000569Effect of Hypoxic Stress–Activated Polo-like Kinase 3 on Corneal Epithelial Wound Healing
Auteurs : Jiawei Lu ; Ling Wang ; Wei Dai ; Luo LuSource :
- Investigative Ophthalmology & Visual Science [ 0146-0404 ] ; 2010.
Abstract
Oxidative stress can affect the process of corneal epithelial wound healing. In the present study, the authors provide a new mechanism involving a hypoxic stress–activated Polo-like kinase 3 (Plk3) in the signaling pathway to elicit activation of the AP-1 transcriptional complex, affecting corneal epithelial wound healing. Removing the Plk3 gene from the mouse eye resulted in a significantly accelerated rate of corneal epithelial wound healing in the absence and presence of hypoxic stress, suggesting that Plk3 plays an important role in mediating oxidative stress–induced delay of corneal epithelial wound healing.
Url:
DOI: 10.1167/iovs.10-5501
PubMed: 20505196
PubMed Central: 3066615
Affiliations:
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